Insights into embryonic chromosomal instability: mechanisms of DNA elimination during mammalian preimplantation development
Mammalian preimplantation embryos often contend with aneuploidy that arose either by the inheritance of meiotic errors from the gametes, or from mitotic mis-segregation events that occurred following fertilization.Regardless of the origin, mis-segregated chromosomes become encapsulated in micronuclei (MN) that are spatially isolated Spreaders from